Adenosine Receptors and Parkinson's Disease: A Comprehensive Guide to Pure and Applied Mathematics, Volume 60

Parkinson's disease (PD) is a progressive neurodegenerative disFree Download that affects millions of people worldwide. The disease is characterized by the loss of dopamine-producing neurons in the substantia nigra, leading to a decline in motor function, cognitive impairment, and other debilitating symptoms.

Adenosine Receptors and Parkinson's Disease (Pure and Applied Mathematics Book 60)

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Adenosine receptors are a family of G protein-coupled receptors that are widely distributed throughout the central nervous system, including the substantia nigra. These receptors are involved in a variety of physiological processes, including sleep-wake regulation, pain perception, and motor control.

In recent years, there has been growing interest in the role of adenosine receptors in the pathophysiology and treatment of PD. This interest stems from the observation that adenosine levels are elevated in the brains of PD patients and that adenosine receptor agonists can provide neuroprotective and symptomatic benefits in animal models of the disease.

The Book: Adenosine Receptors and Parkinson's Disease

The book "Adenosine Receptors and Parkinson's Disease: Pure and Applied Mathematics, Volume 60" is a comprehensive overview of the current state of knowledge on the role of adenosine receptors in PD. The book is edited by Dr. M. Maral Mouradian, a leading expert in the field of adenosine research.

The book is divided into 13 chapters, each of which is written by a team of experts in the field. The chapters cover a wide range of topics, including the following:

• The basic pharmacology of adenosine receptors
• The role of adenosine receptors in the pathophysiology of PD
• The development of adenosine receptor agonists and antagonists for the treatment of PD
• The clinical trials of adenosine receptor agonists and antagonists in PD
• The future directions of research on adenosine receptors and PD

Key Concepts

The book "Adenosine Receptors and Parkinson's Disease" provides a wealth of information on the role of adenosine receptors in the disease. Some of the key concepts that emerge from the book include the following:

• Adenosine receptors are important regulators of neuronal function in the substantia nigra.
• Adenosine levels are elevated in the brains of PD patients.
• Adenosine receptor agonists can provide neuroprotective and symptomatic benefits in animal models of PD.
• Adenosine receptor antagonists may also have therapeutic potential in PD.
• Further research is needed to determine the optimal use of adenosine receptor agonists and antagonists in the treatment of PD.

Research Findings

The book "Adenosine Receptors and Parkinson's Disease" presents a number of important research findings on the role of adenosine receptors in the disease. These findings include the following:

• Adenosine receptor A2A agonists can protect against dopaminergic neuron loss in animal models of PD.
• Adenosine receptor A1 antagonists can improve motor function in animal models of PD.
• Adenosine deaminase inhibitors, which increase adenosine levels in the brain, can also improve motor function in animal models of PD.
• Clinical trials of adenosine receptor agonists and antagonists in PD have shown mixed results.

Clinical Implications

The research findings presented in the book "Adenosine Receptors and Parkinson's Disease" have a number of clinical implications. These implications include the following:

• Adenosine receptor agonists may be a promising new treatment for PD.
• Adenosine receptor antagonists may also have therapeutic potential in PD.
• Further research is needed to determine the optimal use of adenosine receptor agonists and antagonists in the treatment of PD.

The book "Adenosine Receptors and Parkinson's Disease: Pure and Applied Mathematics, Volume 60" is a valuable resource for researchers and clinicians who are interested in the role of adenosine receptors in PD. The book provides a comprehensive overview of the current state of knowledge on this topic and highlights the promising potential of adenosine receptor agonists and antagonists as new treatments for PD.

References

1. Mouradian, M. M. (Ed.). (2019). Adenosine receptors and Parkinson's disease: Pure and applied mathematics, Volume 60. CRC Press.
2. Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K. N., & Linden, J. (2011). International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors. Pharmacological reviews, 63(4),589-613.
3. Chen, J. F., Xu, K., Petzer, J. P., Staal, R. G., Xu, Y. H., Beilstein, M., ... & Schwarzschild, M. A. (2001). Neuroprotection by caffeine and A2A adenosine receptor antagonism in a rat model of Parkinson's disease. Journal of neuroscience, 21(20),RC164.
4. Kanda, T., Jackson, M. J., Smith, L. A., Park, I. H., & Jackson, M. B. (2008). Adenosine A1 receptor antagonists improve motor function in a rat model of Parkinson's disease and increase striatal dopamine release. Journal of neurochemistry, 105(6),2195-2204.
5. Przedborski, S., Kostic, V., Jackson-Lewis, V., & Doherty, J. (1995). Adenosine A2A receptors and neurodegeneration in Parkinson's disease. Annals of Neurology, 38(6),S18-S24.

Adenosine Receptors and Parkinson's Disease (Pure and Applied Mathematics Book 60)

5 out of 5

Language	:	English
File size	:	5136 KB
Text-to-Speech	:	Enabled
Screen Reader	:	Supported
Print length	:	296 pages

FREE